LEWA supplies you with individual chemical pumps and customized system solutions for various areas of application in the chemical industry.
LEWA supplies diaphragm metering pumps and complete metering systems for various processes, e.g. gradient mixers for gradient generation or customer-specific chromatography systems, which are designed precisely to customer specifications.
Low and medium-pressure chromatography, for example
High pressure chromatography
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Chromatography offers a broad spectrum of physical methods for separation and/or analysis of complex mixtures. The components to be separated are divided into two phases: The stationary phase in one column and the mobile phase, which flows through the stationary packing (fluid or gas).
How does chromatography work?
A mixture of different components enters into a liquid or gas process chromatography process. The different separating and chromatography solutions are pumped through the system at different speeds. The separation of the substance mixture is done through interactions of differing strength between the stationary and mobile phases in the system. The smaller the affinity of a molecule for the stationary phase, the shorter the time in a chromatography column and vice versa.
Why is chromatography so special and important?
In the chemical and bioprocessing industry, there is a need to separate a product from a complex mixture and to rid it of contamination. This is one important step in the entire chain of processing (down streaming/cleaning), to produce the product in the needed purity.
Currently there is a wide selection of methods with which the industry can reach these goals. Chromatography is a very special and selective method of separation for numerous reasons, which has been used especially in the production area since decades.
First of all, complex mixtures can be separated with high precision; also very complex molecules, such as proteins, can be gently separated with chromatography, for example. Basically, any soluble or volatile substance can be cleaned, if the correct adsorbent agents and carrier liquid/mobile phase are used under selected and controlled process parameters (temperature, pH value, flow speed, conductivity, etc.)
Chromatographic processes are perfect for the separation or cleanup of sensitive products, espescially established in the pharma sector.